DNA sequencing panels provide incredibly detailed information about the unique gene mutations that are driving your cancer. When analyzed by an expert, this data enables us to choose the most effective targeted therapies for your form of cancer. That’s why CTOAM facilitates genetic testing for all our clients, and the tests we send you for are the most comprehensive panels available.
When getting a detailed genetic tumour analysis done, you must:
Most tests only report well-known mutations. They fail to show lesser-known mutations and do not report variants of unknown significance (VUS) at all. This is problematic because VUS can provide crucial information about what type of targeted therapy will be most beneficial to the patient.
Variants of Unknown Significance (VUS):
For example, take a recent study on patients with prostate cancer. The study showed that the patients with BRCA mutations had significantly higher rates of metastatic disease (17.4% vs 4.4%), and higher rates of stage T3/T4 cancer (40.3% vs 10.8%) than those without BRCA mutations. Critically, this difference was associated with variants of unknown significance.
Having information as to whether a VUS is present is necessary for a correct treatment plan.
That’s why CTOAM’s Cancer Care Research and Advocacy Specialists only use DNA sequencing panels that report all VUS, regardless of the gene. We then use sophisticated DNA and protein modelling methods to determine if the VUS are indeed pathogenic or not – and create a treatment plan that takes the results into consideration.
You need a trained analyst who understands the latest research on VUS, to fully benefit from the data obtained by a comprehensive genetic panel.
To create the most effective treatment plan for your form of cancer, it’s critical to have as much information as possible about your unique mutations. When you become a CTOAM client, you’ll get access to the most advanced and comprehensive sequencing panels. These allow us to identify your unique set of mutations and then choose the best targeted cancer therapy treatment plan for you.
Please contact our Cancer Care Research and Advocacy Specialists today to learn how we can help you access these lifesaving tests and treatments quickly so that you can start moving forward with your recovery as soon as possible.
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