Gamma Knife For Small Recurrent High-Grade Gliomas Following Prior Radical Resection

Gamma Knife utilizes a technique called stereostactic radiosurgery, which uses multiple beams of radiation converging in three dimensions to focus on small volume tumors and permitting intense doses of radiation to be delivered to that volume without affecting surrounding tissues. This review is on Gamma Knife radiosurgery for small recurrent high-grade gliomas following prior radical resection (removal), external-beam radiation therapy, and chemotherapy with temozolomide. Although it only resulted in a median overall survival of 13.5 months, I like this approach because it potentially could be used to target the stem cell niche without affecting surrounding tissues.
Efficacy of gamma knife radiosurgery for small-volume recurrent malignant gliomas after initial radical resection.


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