Valproate: An Anticonvulsant Drug That Greatly Improves Patient Outcome When Used With Radiation/Chemotherapy

Valproate is an anticonvulsant medication often prescribed during chemotherapy. Interestingly, a retrospective cohort analysis of brain cancer patients uncovered evidence that Valproate greatly improved the outcome of patients when used with radiotherapy and standard carboplatin and vincristine chemotherapy. At a 19 month follow up, 14% of patients had complete responses, 36% had partial responses and 23% had stable diseases. I like this approach because it is a cheap and non toxic way of significantly improving treatment outcome.
Potential Role for Valproate in the Treatment of High-Risk Brain Tumors of Childhood-Results from a Retrospective Observational Cohort Study.


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