Diagnosis and Classification of Brain Tumors Using Mass Spectrometry

Brain tissue biopsies obtained during surgery are used to histologically diagnose and grade brain tumors, to discriminate normal from diseased tissue and to determine the best treatments. However, this approach is limited by tissue characterization at the time of surgery.
Desorption electrospray ionization-mass spectrometry (DESI-MS) is a technique that allows for intraoperative examination and classification of brain tissues and provides surgeons, pathologists and oncologists with critical and previously unavailable information to rapidly guide surgical removal and define the actual tumor margins. I like this approach because it provides an accurate method of determining the extent, grade and tumor type at the time of surgery and allows for more accurate removal of pre-malignant and infiltrating malignant tumor tissue without removing essential non-malignant tissue.

Classifying Human Brain Tumors by Lipid Imaging with Mass Spectrometry.

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