Celebrex Induces The Expression Of Angiogenesis In Glioma Cell Lines

Celebrex is a non-steroidal anti-inflammatory drug (NSAID) and selective COX-2 inhibitor used in the treatment of osteoarthritis and rheumatoid arthritis. COX-2 expression is linked to increased angiogenesis and a worse prognosis in patients with malignant gliomas and other cancers. However, contrary to its reported antiangiogenic effects, Celebrex actually induced the expression of angiogenesis in multiple glioma cell lines as well as other cancer cell lines. I like this study because it is further proof that all potential drug interactions need to be considered for effective cancer treatment.
Celecoxib can induce vascular endothelial growth factor expression and tumor angiogenesis.


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