ACCA Slows Glioblastoma Invasiveness By Inhibiting Lactate Removal

Since glioblastoma cancers metabolize glucose to toxic lactic acid at an elevated rate, they survive by removing the excess lactic acid to the tumor microenvironment through transmembrane transporters referred to as monocarboxylate transporters… [Learn More…]

Crenolanib: Targeting PDGFR Mutations Found In Pontine And High Grade Glioma

Crenolanib (CP-868,596), is a drug targets the most commonly amplified region of genome (encoding the PDGF receptor) found in diffuse intrinsic pontine glioma (DIPG) and pediatric high grade glioma (HGG). I like this study because it uses a drug… [Learn More…]

Metformin: A Type 2 Diabetes Drug That Enhances Temozolomide Therapy

Metformin is a drug that has been used for decades for the treatment of type 2 diabetes mellitus. Recent evidence has proven that it enhances the effects of the chemotherapy drug Temozolomide (TMZ), a drug used in the treatment of brain cancers. I… [Learn More…]

TSC: Improving Brain Cancer Sensitivity To Radiation And Chemotherapy

TSC is a drug that enhances oxygen diffusion into the tumor micro-environment, making treatment-resistant brain tumor cells up to three times more susceptible to standard radiation and chemotherapy treatments. I like this approach because it… [Learn More…]

Using TH-302 And Avastin For Treatment Resistant Glioblastoma

TH-302 is a novel small molecule hypoxia-targeted drug that is selectively activated by the low oxygen conditions believed to be induced in tumors by antiangiogenic therapies. Avastin is a monoclonal antibody that affects tumor vasculature… [Learn More…]

Curcumin Selectively Inhibits Glioblastoma Cell Growth

While this information is not new, this study is more evidence that curcumin regulates key cancer causing genes and pathways and should be a daily addition for anyone with brain cancer. The Curry Spice Curcumin Selectively Inhibits Cancer Cells… [Learn More…]

Celebrex Induces The Expression Of Angiogenesis In Glioma Cell Lines

Celebrex is a non-steroidal anti-inflammatory drug (NSAID) and selective COX-2 inhibitor used in the treatment of osteoarthritis and rheumatoid arthritis. COX-2 expression is linked to increased angiogenesis and a worse prognosis in patients with… [Learn More…]

DCVax: Longer Survival Rates Without The Harsh Side Effects Of Standard Treatments

DCVax is an approach that utilizes a patient’s own dendritic cells and extracts of the patient’s own tumor cells to create a personalized treatment. I like this approach because patients who received DCVax showed a median survival of 3 years,… [Learn More…]