Cabozantinib: Treatment For Castration-Resistant Prostate Cancer That Has Metastasized To The Bone

Cabozantinib is a drug that inhibits genes involved in tumor growth, invasion, metastasis and angiogenesis (via VEGFR2). In this trial, 74% of the patients had disease regression and some patients had major complete or partial resolution of prostate… [Learn More…]

Androgen-Deprivation Therapy Before And During Radiotherapy Improves Overall Survival In Prostate Cancer

Short-term androgen-deprivation therapy (ADT) before and during radiotherapy improves cancer control and overall survival in patients with early, localized prostate adenocarcinoma. In this study, patients that received radiotherapy plus… [Learn More…]

NanoKnife: Surgical Resection Using Electrical Fields To Treat Advanced, Unresectable Pancreatic Cancer

NanoKnife is a surgical resection technique in which electrical fields are used to create small defects in a cell’s membrane resulting in cell death. I like this technique because unlike standard surgical techniques, it only destroys the targeted… [Learn More…]

CBP501 Increases Efficiency Of Pemetrexed And Cisplatin, Providing New Option For Relapsed Patients

CBP501 is a drug that increases the cytotoxicity of DNA-damaging anticancer drugs against cancer cells without increasing adverse effects. In this study, CBP501 will be combined with Pemetrexed and Cisplatin. I like this approach because it… [Learn More…]

Using Patient Derived Tumor Infiltrating Lymphocytes To Treat Metastatic Melanoma

Tumor infiltrating lymphocytes (TIL) are white blood cells that are taken from a patients tumor tissue, expanded and primed (activated) against known melanoma proteins, and injected back into the patient. In an ongoing trial, 50–75% of the… [Learn More…]

Trastuzumab: A Breast Cancer Drug Effective In Treating Advanced Gastric Cancer

Trastuzumab is a monoclonal antibody that has been significant in treating HER-2 breast cancers. Recently, it has been shown to prolong life in patients with a malignant epithelial condition. Since Trastuzumab also regulates angiogenesis and… [Learn More…]

Eribulin: A Drug Derived From Sea Sponges Used To Treat Resistant Metastatic Breast Cancer

Eribulin is a drug derived from a sea sponge that interfers with cancer cell division and growth (like standard chemo). I like this drug because it is one of the few drugs that improves overall survival in women with metastatic breast cancer whose… [Learn More…]

CDX-011: Selective Killing Of Breast Cancer Cells By Targeting Glycoprotein NMB

CDX-011 is an antibody attached to a cancer killing drug. The antibody delivers the drug to cancer cells by attaching to a protein called glycoprotein NMB (GPNMB) that is expressed on the surface of breast cancer cells. I like this approach… [Learn More…]

Valproate: An Anticonvulsant Drug That Greatly Improves Patient Outcome When Used With Radiation/Chemotherapy

Valproate is an anticonvulsant medication often prescribed during chemotherapy. Interestingly, a retrospective cohort analysis of brain cancer patients uncovered evidence that Valproate greatly improved the outcome of patients when used with… [Learn More…]

Selective killing Of Brain Tumor Cells Using Magnetic Nanoparticles

In this approach, magnetic biocompatible iron-oxide nanoparticles are directly injected into the tumor and subsequently stimulated by an external alternating magnetic field. When this occurs, the nanoparticles generate heat selectively killing the… [Learn More…]