LEUKEMIA (CLL)

This blog is a collection of my favorite new treatments for CLL currently available through clinical trials. The start of each post contains a brief description of the approach, reasons I included it and a link to the trial website.

Idelalisib: Could This ‘B’ the Ideal Treatment For Chronic Lymphocytic Leukemia (CLL)?

  The B-cell–receptor signaling pathway plays a key role in the pathogenesis of Chronic Lymphocytic Leukemia (CLL) and signaling is mediated in part by the activation of the delta isoform of phosphatidylinositol 3-kinase (PI3Kdelta), which… [Learn More…]

Obinutuzumab:Targeting The CD’s Of CLL.

CD20 is a cell surface protein commonly found in B-cell chronic lymphocytic leukemia (CLL). In physically fit patients with previously untreated CLL, chemotherapy and the monoclonal CD20 antibody rituximab can significantly increase overall survival… [Learn More…]

Advanced Stem Cell Transplants for Blood Cancer Patients

For patients suffering from blood cancers, a stem cell transplant can be a life saving procedure. With allogeneic stem cell transplants, the stem cells are taken from a matched donor (typically a family member) and infused into an immune suppressed… [Learn More…]

Determining Time to First Treatment for Patients With Chronic Lymphocytic Leukemia (CLL)

The time to progression for CLL can vary greatly between patients with some patients never needing treatment and others with aggressive disease requiring early treatment. For newly diagnosed patients, the uncertainty of the current “wait-and-see… [Learn More…]