LEUKEMIA (AML)

This blog is a collection of my favorite new treatments for AML currently available through clinical trials. The start of each post contains a brief description of the approach, reasons I included it and a link to the trial website.

Arsenic And “New Lace” – Not Just For Murderous Old Ladies!

While the standard treatment for acute promyelocytic leukemia (APL) using all-trans retinoic acid (ATRA) with chemotherapy typically results in cure rates exceeding 80%, hematologic toxicity is an issue. In this recent phase 3 clinical trial on… [Learn More…]

Quizartinib Significantly Increases Survival For AML Patients With FLT3 Mutations

The FLT3-ITD tandem duplication mutation is the most common mutation in AML and this mutation renders the FLT3 enzyme constitutively active, sending a constant growth signal to malignant myeloid cells. The presence of this mutation results in a… [Learn More…]

Advanced Stem Cell Transplants for Blood Cancer Patients

For patients suffering from blood cancers, a stem cell transplant can be a life saving procedure. With allogeneic stem cell transplants, the stem cells are taken from a matched donor (typically a family member) and infused into an immune suppressed… [Learn More…]

Sorfenib For AML Patients With The FLT3-ITD Mutation

Sorfenib slows the spread of cancer cells by inhibiting angiogenesis (VEGFR-2,-3) as well as growth factor receptors (PDGFR, KIT). Recently, it has been used for AML patients with the FLT3-ITD mutation, the most common mutation in AML patients. I… [Learn More…]

Natural Killer Cell Based Non-Myeloablative Transplantation For Acute Myeloid Leukemia

Non-myeloablative transplantation provides a therapeutic strategy for treating patients with active infection who cannot tolerate conventional myeloablative transplantation using high-dose chemoradiotherapy. Besides having less side effects (due to… [Learn More…]