BREAST CANCER

This blog is a collection of my favorite new treatments for breast cancer currently available through clinical trials. The start of each post contains a brief description of the approach, reasons I included it and a link to the trial website.

New Treatment For ER Positive Breast Cancer: Checking Up On Cell Cycle Inhibitors.

One of the common mechanisms involved in advanced stage metastatic ER positive breast cancer is amplification of cell dependent kinases (CDKs) 4/6. Over activation of these two genes enables tumor cell progression from G1 to S phase of the cell… [Learn More…]

Anastrozole And Fulvestrant For Post Menopausal, Estrogen Positive Breast Cancer.

  Anastrozole and Fulvestrant are two drugs that are commonly used to treat estrogen (ER) positive breast cancers in postmenopausal patients. Anastrozole works by inhibiting estrogen synthesis while Fulvestrant binds and accelerates… [Learn More…]

Pertuzumab: The New Kid on “HER” Block

Approximately 20% of all breast cancers are caused by the oncogenic human epidermal growth factor receptor 2 (HER2) and although trastuzumab has led to significant improvements in treating HER2-positive breast cancers, many patients develop… [Learn More…]

Everolimus and Exemestane for Postmenopausal Women with Letrozole or Anastrozole-Resistant Breast Cancers

Everolimus is a drug that targets the mTOR pathway, which is over-activated in many cancers and associated with resistant to hormonal therapy in breast cancers. In this study, everolimus was used in combination with exemestane to treat… [Learn More…]

Positive Phase II Data Support Entinostat Treatment for Advanced Breast Cancer

Entinostat is an inhibitor of class I histone deacetylase, an enzyme involved in epigenetic gene regulation commonly altered in cancers. Importantly, doctors can perform a simple test to determine whether or not entinostat will be effective in a… [Learn More…]

Exemestane Offers New Option for Breast-Cancer Prevention

Exemestane is an aromatase inhibitor that substantially reduces the risk of invasive breast cancer in postmenopausal women at high risk of developing the disease. A 3yr follow up found that patients who took exemestane were 65% less likely to… [Learn More…]

Brachytherapy for Breast Cancer with Metastasis to the Brain

Brachytherapy involves implanting tiny radioactive seeds near to tumor tissue, resulting in a high dosage to the tumor and minimal damage to healthy surrounding tissues and organs. Regardless of where a tumor originates, treating brain tumors… [Learn More…]

Adjuvant Endocrine Therapy plus Zoledronic Acid in Premenopausal Women

Zoledronic acid is a drug used to treat bone metastasis. Addition of Zoledronic acid to either tamoxifen or anastrozole increased disease-free survival by 36% compared with either tamoxifen or anastrozole alone. At a median follow-up of just under… [Learn More…]

Eribulin: A Drug Derived From Sea Sponges Used To Treat Resistant Metastatic Breast Cancer

Eribulin is a drug derived from a sea sponge that interfers with cancer cell division and growth (like standard chemo). I like this drug because it is one of the few drugs that improves overall survival in women with metastatic breast cancer whose… [Learn More…]

CDX-011: Selective Killing Of Breast Cancer Cells By Targeting Glycoprotein NMB

CDX-011 is an antibody attached to a cancer killing drug. The antibody delivers the drug to cancer cells by attaching to a protein called glycoprotein NMB (GPNMB) that is expressed on the surface of breast cancer cells. I like this approach… [Learn More…]