BRAIN CANCER

This blog is a collection of my favorite new treatments for brain cancers currently available through clinical trials. The start of each post contains a brief description of the approach, reasons I included it and a link to the trial website.

Amazing Results From ICT-107 Glioblastoma Clinical Trial

ICT-107 is a dendritic cell-based vaccine targeting multiple tumor associated antigens for glioblastoma and is showing an 80.2% overall survival at 2yrs and 55% overall survival at 3yrs, with 38% of patients disease free at 3yrs…compared to a… [Learn More…]

Valproate: An Anticonvulsant Drug That Greatly Improves Patient Outcome When Used With Radiation/Chemotherapy

Valproate is an anticonvulsant medication often prescribed during chemotherapy. Interestingly, a retrospective cohort analysis of brain cancer patients uncovered evidence that Valproate greatly improved the outcome of patients when used with… [Learn More…]

Selective killing Of Brain Tumor Cells Using Magnetic Nanoparticles

In this approach, magnetic biocompatible iron-oxide nanoparticles are directly injected into the tumor and subsequently stimulated by an external alternating magnetic field. When this occurs, the nanoparticles generate heat selectively killing the… [Learn More…]

ACCA Slows Glioblastoma Invasiveness By Inhibiting Lactate Removal

Since glioblastoma cancers metabolize glucose to toxic lactic acid at an elevated rate, they survive by removing the excess lactic acid to the tumor microenvironment through transmembrane transporters referred to as monocarboxylate transporters… [Learn More…]

Crenolanib: Targeting PDGFR Mutations Found In Pontine And High Grade Glioma

Crenolanib (CP-868,596), is a drug targets the most commonly amplified region of genome (encoding the PDGF receptor) found in diffuse intrinsic pontine glioma (DIPG) and pediatric high grade glioma (HGG). I like this study because it uses a drug… [Learn More…]

Metformin: A Type 2 Diabetes Drug That Enhances Temozolomide Therapy

Metformin is a drug that has been used for decades for the treatment of type 2 diabetes mellitus. Recent evidence has proven that it enhances the effects of the chemotherapy drug Temozolomide (TMZ), a drug used in the treatment of brain cancers. I… [Learn More…]

TSC: Improving Brain Cancer Sensitivity To Radiation And Chemotherapy

TSC is a drug that enhances oxygen diffusion into the tumor micro-environment, making treatment-resistant brain tumor cells up to three times more susceptible to standard radiation and chemotherapy treatments. I like this approach because it… [Learn More…]

Using TH-302 And Avastin For Treatment Resistant Glioblastoma

TH-302 is a novel small molecule hypoxia-targeted drug that is selectively activated by the low oxygen conditions believed to be induced in tumors by antiangiogenic therapies. Avastin is a monoclonal antibody that affects tumor vasculature… [Learn More…]

Curcumin Selectively Inhibits Glioblastoma Cell Growth

While this information is not new, this study is more evidence that curcumin regulates key cancer causing genes and pathways and should be a daily addition for anyone with brain cancer. The Curry Spice Curcumin Selectively Inhibits Cancer Cells… [Learn More…]

Celebrex Induces The Expression Of Angiogenesis In Glioma Cell Lines

Celebrex is a non-steroidal anti-inflammatory drug (NSAID) and selective COX-2 inhibitor used in the treatment of osteoarthritis and rheumatoid arthritis. COX-2 expression is linked to increased angiogenesis and a worse prognosis in patients with… [Learn More…]