BRAIN CANCER

This blog is a collection of my favorite new treatments for brain cancers currently available through clinical trials. The start of each post contains a brief description of the approach, reasons I included it and a link to the trial website.

Update of ICT-107 Glioblastoma Clinical Trial: I C Great Potential In Dendritic Cell Therapies.

We originally posted the results from the ICT-107 Glioblastoma (GBM) Clinical Trial back in September 29, 2011 and marked it as a potential game changer in treatment of brain tumors. In short, ICT-107 is a vaccine based on dendritic cells, which… [Learn More…]

Can’t Stand The Heat: Targeting Heat Shock Proteins In Glioblastomas.

HSPPC-96 is a prophage vaccine manufactured from a patient’s own tumor cells that targets tumor specific heat shock proteins (HSP). HSPs are proteins found in all types of cells. When cells are exposed to increased temperatures or other stresses,… [Learn More…]

NOVOCURE TTF UPDATE:

The NovoTTF-100A system is a portable, non-invasive medical device that slows and reverses tumor growth by creating low intensity, alternating electric fields within the tumor. A recent update on the GBM patients from the original pilot study of… [Learn More…]

Interlaced Chemotherapy For Recurrent High-Grade Gliomas

Many conventional cytotoxic chemotherapies exert their effects during the S or M phase of the cell cycle. One of the major drawbacks of these drugs is that the number of tumor cells destroyed is limited to those cells that happen to be in S or M… [Learn More…]

MRI for Pre-surgical Detection of Mutations in Brain Tumors

Mutations in the isocitrate dehydrogenase genes (IDH1 and IDH2) are found in roughly 70 % of low and intermediate-grade gliomas, and the presence of these mutations means patients generally survive longer, but don’t respond as well to standard… [Learn More…]

Diagnosis and Classification of Brain Tumors Using Mass Spectrometry

Brain tissue biopsies obtained during surgery are used to histologically diagnose and grade brain tumors, to discriminate normal from diseased tissue and to determine the best treatments. However, this approach is limited by tissue characterization… [Learn More…]

NovoTTF-100A Provides Non-invasive Treatment Options for Recurrent Glioblastomas

The NovoTTF-100A system is a portable, non-invasive medical device that slows and reverses tumor growth by creating low intensity, alternating electric fields within the tumor. In this study, continuous NovoTTF-100A monotherapy (20-24 hours per day,… [Learn More…]

Rindopepimut Significantly Increases Overall Survival of Treatment-Resistant Glioblastoma Patients

Rindopepimut is a vaccine that targets the epidermal growth factor receptor variant III mutation (EGFRvIII), which occurs in 31% of glioblastoma multiforme cases and is linked to poor long-term survival regardless of other factors such as extent of… [Learn More…]

Brachytherapy for Cancers of the Brain

Brachytherapy involves implanting tiny radioactive seeds near to tumor tissue, resulting in a high dosage to the tumor and minimal damage to healthy surrounding tissues and organs. Regardless of where a tumor originates, treating brain tumors… [Learn More…]

Chemotherapy Reduces Overall Survival in Children with Low-Grade Glioma

In this retrospective review of children with inoperable intracranial low-grade glioma, it was found that children treated with chemotherapy prior to radiation therapy had a lower 10yr overall survival rate of 85%, compared to 92% for children who… [Learn More…]