New Evidence that Widespread Breast Screening with Mammography is not Effective

If you are still putting great stock in the process of mammography for breast cancer screening it’s time to rethink your strategy. The Journal of the American Medicine Association (JAMA) recently published an article that echoes the data being… [Learn More…]

Idelalisib: Could This ‘B’ the Ideal Treatment For Chronic Lymphocytic Leukemia (CLL)?

  The B-cell–receptor signaling pathway plays a key role in the pathogenesis of Chronic Lymphocytic Leukemia (CLL) and signaling is mediated in part by the activation of the delta isoform of phosphatidylinositol 3-kinase (PI3Kdelta), which… [Learn More…]

Obinutuzumab:Targeting The CD’s Of CLL.

CD20 is a cell surface protein commonly found in B-cell chronic lymphocytic leukemia (CLL). In physically fit patients with previously untreated CLL, chemotherapy and the monoclonal CD20 antibody rituximab can significantly increase overall survival… [Learn More…]

Update of ICT-107 Glioblastoma Clinical Trial: I C Great Potential In Dendritic Cell Therapies.

We originally posted the results from the ICT-107 Glioblastoma (GBM) Clinical Trial back in September 29, 2011 and marked it as a potential game changer in treatment of brain tumors. In short, ICT-107 is a vaccine based on dendritic cells, which… [Learn More…]

Multiple Myeloma And Aspirin: Willow Bark Hit The Big Time

  Inflammation is a factor in many types of cancer including multiple myeloma (MM). Aspirin inhibits several pro-inflammation signalling pathways mediated by nuclear factor NFκB and COX-2. Both of these pathways and their downstream targets… [Learn More…]

New Treatment For ER Positive Breast Cancer: Checking Up On Cell Cycle Inhibitors.

One of the common mechanisms involved in advanced stage metastatic ER positive breast cancer is amplification of cell dependent kinases (CDKs) 4/6. Over activation of these two genes enables tumor cell progression from G1 to S phase of the cell… [Learn More…]

EARLY DETECTION OF MUCINOUS AND GRANULOSE CELL TUMORS:WHAT INHIBINS YOU COULD KILL YOU!

Granulosa cell and mucinous epithelial tumors are rare types of ovarian cancer. Inhibins are a family of growth factors comprised of several different species that are secreted in ovarian follicles and are also produced by granulosa cell tumors and… [Learn More…]

Can’t Stand The Heat: Targeting Heat Shock Proteins In Glioblastomas.

HSPPC-96 is a prophage vaccine manufactured from a patient’s own tumor cells that targets tumor specific heat shock proteins (HSP). HSPs are proteins found in all types of cells. When cells are exposed to increased temperatures or other stresses,… [Learn More…]

Extinguishing The Fire Before The Flame: Early Treatment For High Risk Smouldering Multiple Myeloma

  For patients with smouldering multiple myeloma, the standard of care is observation until symptoms develop. However, this approach does not identify high-risk patients who may benefit from early intervention. In this phase 3 trial,… [Learn More…]

Arsenic And “New Lace” – Not Just For Murderous Old Ladies!

While the standard treatment for acute promyelocytic leukemia (APL) using all-trans retinoic acid (ATRA) with chemotherapy typically results in cure rates exceeding 80%, hematologic toxicity is an issue. In this recent phase 3 clinical trial on… [Learn More…]