JX-594: A Targeted Oncolytic Poxvirus, Followed by Sorafenib in Hepatocellular Carcinoma

JX-594 is a targeted and granulocyte-macrophage colony stimulating factor (GM-CSF) expressing oncolytic poxvirus designed to selectively replicate in and destroy cancer cells through viral oncolysis and tumor-specific immunity. In this trial,… [Learn More…]

NICO Myriad: An Amazing New Surgical Tool!

This amazing new tool allows for minimally invasive brain tumor removal combined with extraction of live tumor samples in order to determine the most effective treatment protocol. I like this tool because it is highly innovative, has a modular… [Learn More…]

PET-MRI: The Benefits Of PET-CT Without The Radiation

PET-MRI is better than PET-CT at showing detailed anatomical information such as angiogenesis. I like this technique because it allows identification of tumors without the use of ionizing radiation, which can be important for repeated scanning to… [Learn More…]

Gamma Knife For Small Recurrent High-Grade Gliomas Following Prior Radical Resection

Gamma Knife utilizes a technique called stereostactic radiosurgery, which uses multiple beams of radiation converging in three dimensions to focus on small volume tumors and permitting intense doses of radiation to be delivered to that volume… [Learn More…]

Using Genomic Data To Improve The Therapeutic Stratification Of Patients

This AML project will increase the use of AML genomic data to improve the therapeutic stratification of patients, thereby leading to more personalized treatment of AML and hopefully, improved outcomes. Personalized Medicine on the Horizon for BC… [Learn More…]

Sorfenib For AML Patients With The FLT3-ITD Mutation

Sorfenib slows the spread of cancer cells by inhibiting angiogenesis (VEGFR-2,-3) as well as growth factor receptors (PDGFR, KIT). Recently, it has been used for AML patients with the FLT3-ITD mutation, the most common mutation in AML patients. I… [Learn More…]

Natural Killer Cell Based Non-Myeloablative Transplantation For Acute Myeloid Leukemia

Non-myeloablative transplantation provides a therapeutic strategy for treating patients with active infection who cannot tolerate conventional myeloablative transplantation using high-dose chemoradiotherapy. Besides having less side effects (due to… [Learn More…]

Itraconazole: An Antifungal Drug That Delays Need For Chemo In Advanced Prostate Cancer

Itraconazole is an antifungal drug commonly used to treat nail fungus. Recent research has shown that it also disrupts a key cancer-initiating pathway and appears to prevent angiogenesis in prostate cancers. I like this approach because it… [Learn More…]

Cabozantinib: Treatment For Castration-Resistant Prostate Cancer That Has Metastasized To The Bone

Cabozantinib is a drug that inhibits genes involved in tumor growth, invasion, metastasis and angiogenesis (via VEGFR2). In this trial, 74% of the patients had disease regression and some patients had major complete or partial resolution of prostate… [Learn More…]

Androgen-Deprivation Therapy Before And During Radiotherapy Improves Overall Survival In Prostate Cancer

Short-term androgen-deprivation therapy (ADT) before and during radiotherapy improves cancer control and overall survival in patients with early, localized prostate adenocarcinoma. In this study, patients that received radiotherapy plus… [Learn More…]