ACCA Slows Glioblastoma Invasiveness By Inhibiting Lactate Removal

Since glioblastoma cancers metabolize glucose to toxic lactic acid at an elevated rate, they survive by removing the excess lactic acid to the tumor microenvironment through transmembrane transporters referred to as monocarboxylate transporters (MCTs). ACCA is a small-molecule inhibitor of these lactate transporters. I like this approach because it targets a process that brain tumors require in order to survive.
Metabolic Targeting of Lactate Efflux by Malignant Glioma Inhibits Invasiveness and Induces Necrosis: An In-Vivo Study.


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