Archives for October 2011

Vandetanib for Locally Advanced or Metastatic Medullary Thyroid Cancer (MTC)

Medullary thyroid cancer (MTC) can usually be treated with surgery. However, treatment options for patients with unresectable, recurrent or metastatic MTC are limited. Mutations in the RET gene are common in sporadic MTC with the most common… [Learn More…]

Exemestane Offers New Option for Breast-Cancer Prevention

Exemestane is an aromatase inhibitor that substantially reduces the risk of invasive breast cancer in postmenopausal women at high risk of developing the disease. A 3yr follow up found that patients who took exemestane were 65% less likely to… [Learn More…]

Cabozantinib for Castration-Resistant Prostate Cancer

Cabozantinib is a multiple tyrosine kinase inhibitor that blocks the vascular endothelial growth factor receptor (VEGFR) and the receptor of hepatocyte growth factor (C-MET), resulting in significant benefits for patients with metastatic prostate… [Learn More…]

T Cell Therapy for EBV-Positive Nasopharyngeal Carcinoma

One of the causes of Nasopharyngeal Carcinoma (NPC) is an oncogenic protein made by the Epstein-Barr virus (EBV), referred to as the latent membrane protein 1 (LMP1). EBV-specific cytotoxic T cells (EBV-CTLs) therapy is a process where T-cells are… [Learn More…]

Thalidomide and Radiotherapy for Metastatic Angiosarcoma

Thalidomide is a sedative that was originally designed to cure morning sickness  but was recalled after it was found to cause severe birth defects. In this study, a 62 year old male with metastatic angiosarcoma was treated with a combination of… [Learn More…]

Brachytherapy for Cancers of the Brain

Brachytherapy involves implanting tiny radioactive seeds near to tumor tissue, resulting in a high dosage to the tumor and minimal damage to healthy surrounding tissues and organs. Regardless of where a tumor originates, treating brain tumors… [Learn More…]

Brachytherapy for Breast Cancer with Metastasis to the Brain

Brachytherapy involves implanting tiny radioactive seeds near to tumor tissue, resulting in a high dosage to the tumor and minimal damage to healthy surrounding tissues and organs. Regardless of where a tumor originates, treating brain tumors… [Learn More…]

Chemotherapy Reduces Overall Survival in Children with Low-Grade Glioma

In this retrospective review of children with inoperable intracranial low-grade glioma, it was found that children treated with chemotherapy prior to radiation therapy had a lower 10yr overall survival rate of 85%, compared to 92% for children who… [Learn More…]

Multi-Session Gamma Knife Radiosurgery for Cancers of the Brain

Gamma Knife is a form of external stereostatic radiosurgery that uses 192 smaller beams of radiation to converge on a precise area of the body. With an accuracy of 0.5mm, Gamma Knife has minimal effects on surrounding healthy tissues and can be used… [Learn More…]

Nilotinib for Treatment of Newly Diagnosed Chronic Phase, Philadelphia Chromosome-Positive, CML

Imatinib was one of the first rationally designed drugs to specifically target the BCR-ABL fusion gene found in CML. Unfortunately, many patients eventually develop resistance to Imatinib. Nilotinib is a new drug designed to treat… [Learn More…]