Archives for August 2011

CBP501 Increases Efficiency Of Pemetrexed And Cisplatin, Providing New Option For Relapsed Patients

CBP501 is a drug that increases the cytotoxicity of DNA-damaging anticancer drugs against cancer cells without increasing adverse effects. In this study, CBP501 will be combined with Pemetrexed and Cisplatin. I like this approach because it… [Learn More…]

Using Patient Derived Tumor Infiltrating Lymphocytes To Treat Metastatic Melanoma

Tumor infiltrating lymphocytes (TIL) are white blood cells that are taken from a patients tumor tissue, expanded and primed (activated) against known melanoma proteins, and injected back into the patient. In an ongoing trial, 50–75% of the… [Learn More…]

Trastuzumab: A Breast Cancer Drug Effective In Treating Advanced Gastric Cancer

Trastuzumab is a monoclonal antibody that has been significant in treating HER-2 breast cancers. Recently, it has been shown to prolong life in patients with a malignant epithelial condition. Since Trastuzumab also regulates angiogenesis and… [Learn More…]

Eribulin: A Drug Derived From Sea Sponges Used To Treat Resistant Metastatic Breast Cancer

Eribulin is a drug derived from a sea sponge that interfers with cancer cell division and growth (like standard chemo). I like this drug because it is one of the few drugs that improves overall survival in women with metastatic breast cancer whose… [Learn More…]

CDX-011: Selective Killing Of Breast Cancer Cells By Targeting Glycoprotein NMB

CDX-011 is an antibody attached to a cancer killing drug. The antibody delivers the drug to cancer cells by attaching to a protein called glycoprotein NMB (GPNMB) that is expressed on the surface of breast cancer cells. I like this approach… [Learn More…]

Valproate: An Anticonvulsant Drug That Greatly Improves Patient Outcome When Used With Radiation/Chemotherapy

Valproate is an anticonvulsant medication often prescribed during chemotherapy. Interestingly, a retrospective cohort analysis of brain cancer patients uncovered evidence that Valproate greatly improved the outcome of patients when used with… [Learn More…]

Selective killing Of Brain Tumor Cells Using Magnetic Nanoparticles

In this approach, magnetic biocompatible iron-oxide nanoparticles are directly injected into the tumor and subsequently stimulated by an external alternating magnetic field. When this occurs, the nanoparticles generate heat selectively killing the… [Learn More…]

ACCA Slows Glioblastoma Invasiveness By Inhibiting Lactate Removal

Since glioblastoma cancers metabolize glucose to toxic lactic acid at an elevated rate, they survive by removing the excess lactic acid to the tumor microenvironment through transmembrane transporters referred to as monocarboxylate transporters… [Learn More…]

Crenolanib: Targeting PDGFR Mutations Found In Pontine And High Grade Glioma

Crenolanib (CP-868,596), is a drug targets the most commonly amplified region of genome (encoding the PDGF receptor) found in diffuse intrinsic pontine glioma (DIPG) and pediatric high grade glioma (HGG). I like this study because it uses a drug… [Learn More…]

Metformin: A Type 2 Diabetes Drug That Enhances Temozolomide Therapy

Metformin is a drug that has been used for decades for the treatment of type 2 diabetes mellitus. Recent evidence has proven that it enhances the effects of the chemotherapy drug Temozolomide (TMZ), a drug used in the treatment of brain cancers. I… [Learn More…]